Periodontal Disease as an Indicator of General Health: Insights from a Cross-Sectional Study
DOI:
https://doi.org/10.65293/jbkcd.v2i01.28Keywords:
Periodontal Disease, Obesity, Diabetes, Lung Function, FEV1, HbA1c, Smoking, HypertensionAbstract
Objective: This study examined associations between periodontal disease, metabolic health markers, and pulmonary function in a diverse population.
Study Design: A cross-sectional study
Place and Duration of Study: Department of Periodontology, Sardar Begum Dental College, Peshawar, from August 2023 to December 2023.
Materials and Methods: A total of 310 participants were assessed for demographic characteristics, smoking status, body mass index (BMI), glycated hemoglobin (HbA1c), forced expiratory volume in one second (FEV1%), and periodontal health. Participants were categorized by periodontal severity, BMI, HbA1c, and lung function status. Intergroup comparisons were analyzed with significance set at p < 0.05.
Results: Of the participants, 48.4% were male, 25.8% current smokers, 19.4% diabetic, and 29% hypertensive. Severe periodontal disease affected 16.1%, while 22.6% were obese. Severity of periodontal disease was significantly associated with age, smoking, diabetes, hypertension, and obesity (p < 0.001). Individuals with severe periodontal disease showed higher BMI (29.3 ± 4.9), elevated HbA1c (6.8 ± 0.9), and lower FEV1% (65.8 ± 12.7), all statistically significant (p < 0.001). Pulmonary function also declined in participants with obesity and diabetes, and those with higher HbA1c were more likely to present with severe impairment (FEV1% <60%) (p< 0.001).
Conclusion: Periodontal disease, metabolic disorders, and reduced lung function are strongly interrelated. The findings highlight the importance of integrated healthcare strategies targeting oral health, metabolic control, and respiratory function to reduce the overall burden of disease.
References
1. Usher AK, Stockley RS. The link between chronic periodontitis and COPD: a common role for the neutrophil? BMC Med. 2023;11:241.
2. Goracci C, Franchi L, Vichi A, Ferrari M. Accuracy, reliability, and efficiency of intraoral scanners for full-arch impressions: a systematic review of the clinical evidence. Eur J Orthod [Internet]. 2016;38(4):422–8. Available from: http://dx.doi.org/10.1093/ejo/cjv077
3. Hare MJL, Topliss DJ. Classification and laboratory diagnosis of diabetes mellitus. In: Endocrinology and Diabetes. Cham: Springer International Publishing; 2022. p. 303–13.
4. Okamoto N, Amano N, Nakamura T, Yanagi M. Relationship between tooth loss, low masticatory ability, and nutritional indices in the elderly: a cross-sectional study. BMC Oral Health [Internet]. 2019;19(1):110. Available from: http://dx.doi.org/10.1186/s12903-019-0778-5
5. Sun K-T, Chen S-C, Lin C-L, Hsu J-T, Chen I-A, Wu I-T, et al. The association between Type 1 diabetes mellitus and periodontal diseases. J Formos Med Assoc [Internet]. 2019;118(6):1047–54. Available from: http://dx.doi.org/10.1016/j.jfma.2018.10.012
6. Kataoka S, Kimura M, Yamaguchi T, Egashira K, Yamamoto Y, Koike Y, et al. A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey. BMC Oral Health [Internet]. 2021;21(1):644. Available from: http://dx.doi.org/10.1186/s12903-021-01990-6
7. Park S-Y, Ahn S, Lee J-T, Yun P-Y, Lee YJ, Lee JY, et al. Periodontal inflamed surface area as a novel numerical variable describing periodontal conditions. J Periodontal Implant Sci [Internet]. 2017;47(5):328. Available from: http://dx.doi.org/10.5051/jpis.2017.47.5.328
8. Genco RJ, Graziani F, Hasturk H. Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus. Periodontol 2000 [Internet]. 2020;83(1):59–65. Available from: http://dx.doi.org/10.1111/prd.12271
9. Lee JY, Divaris K. The ethical imperative of addressing oral health disparities: a unifying framework: A unifying framework. J Dent Res [Internet]. 2014;93(3):224–30. Available from: http://dx.doi.org/10.1177/0022034513511821
10. Pabisch S, Akabane C, Wagermaier W, Roschger A, Ogura T, Hyodo R, et al. The nanostructure of murine alveolar bone and its changes due to type 2 diabetes. J Struct Biol [Internet]. 2016;196(2):223–31. Available from: http://dx.doi.org/10.1016/j.jsb.2016.09.007
11. Kato H, Taguchi Y, Tominaga K, Kimura D, Yamawaki I, Noguchi M, et al. High glucose concentrations suppress the proliferation of human periodontal ligament stem cells and their differentiation into osteoblasts. J Periodontol [Internet]. 2016;87(4):e44-51. Available from: http://dx.doi.org/10.1902/jop.2015.150474
12. Zheng J, Chen S, Albiero ML, Vieira GHA, Wang J, Feng JQ, et al. Diabetes activates periodontal ligament fibroblasts via NF-κB in vivo. J Dent Res [Internet]. 2018;97(5):580–8. Available from: http://dx.doi.org/10.1177/0022034518755697
13. Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol [Internet]. 2015;15(1):30–44. Available from: http://dx.doi.org/10.1038/nri3785
14. Hobbins S, Chapple IL, Sapey E, Stockley RA. Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors? Int J Chron Obstruct Pulmon Dis [Internet]. 2017;12:1339–49. Available from: http://dx.doi.org/10.2147/COPD.S127802
15. Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, et al. Association between dietary quality of rural older adults and self-reported food avoidance and food modification due to oral health problems: Food avoidance and modification and dietary quality. J Am Geriatr Soc [Internet]. 2010;58(7):1225–32. Available from: http://dx.doi.org/10.1111/j.1532-5415.2010.02909.x
16. Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions: Classification and case definitions for periodontitis. J Periodontol [Internet]. 2018;89 Suppl 1:S173–82. Available from: http://dx.doi.org/10.1002/JPER.17-0721
17. Takeuchi N, Ekuni D, Yamamoto T, Morita M. Relationship between the prognosis of periodontitis and occlusal force during the maintenance phase: a cohort study. J Periodontal Res. 2021;45(5):612–7.
18. Priyamvara A, Dey AK, Bandyopadhyay D, Katikineni V, Zaghlol R, Basyal B, et al. Periodontal inflammation and the risk of cardiovascular disease. Curr Atheroscler Rep [Internet]. 2020;22(7):28. Available from: http://dx.doi.org/10.1007/s11883-020-00848-6
19. Kosaka T, Ono T, Yoshimuta Y, Kida M, Kikui M, Nokubi T, et al. The effect of periodontal status and occlusal support on masticatory performance: the Suita study. J Clin Periodontol [Internet]. 2014;41(5):497–503. Available from: http://dx.doi.org/10.1111/jcpe.12241
20. Shi Q, Zhang B, Xing H, Yang S, Xu J, Liu H. Patients with chronic obstructive pulmonary disease suffer from worse periodontal health: evidence from a meta-analysis. Front Physiol. 2022;9.
21. Guo ZG, Li C, Zhong JK, Tu Y, Xie D. Laboratory investigation of dysfunctional HDL. Chem Phys Lipids [Internet]. 2012;165(1):32–7. Available from: http://dx.doi.org/10.1016/j.chemphyslip.2011.10.005
22. Malinovschi A, Johannessen A. Post-bronchodilator reference values for spirometry: consequences of using pre- or post-bronchodilator norms. Am J RespirCrit Care Med. 2023;208(4):461–71.
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